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desvenlafaxine will improve the stage or influence of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Keep track of. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) reduce the CYP2D6 substrate dose by approximately fifty%; no dosage adjustment required with desvenlafaxine doses seven consecutive time